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Title:
PHARMACEUTICAL PREPARATION FOR NEW USE, AS WELL AS PROCESS FOR PRODUCTION OF THE SAME
Document Type and Number:
Japanese Patent JP2011137048
Kind Code:
A
Abstract:

To provide a method for using mercaptoethane sulfonate-sodium (Mesna) to increase the solubility of Ifosfamide in storage-stable, concentrated and/or highly-concentrated (supersaturated) aqueous pharmaceutical preparations for parenteral administration as well as a process for their production.

The Ifosfamide of storage stabilized concentration is preferably prepared by using Mesna as a solubility increasing agent relating to the physical properties of Ifosfamide in a concentration range of about 10% (w.t/vol.) to 50% (wt./vol.).


Inventors:
ROESSLER BERTHOLD
Application Number:
JP2011088613A
Publication Date:
July 14, 2011
Filing Date:
April 12, 2011
Export Citation:
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Assignee:
BAXTER INT
BAXTER HEALTHCARE SA
International Classes:
A61K31/675; A61K9/08; A61K9/19; A61K31/185; A61K31/66; A61K45/06; A61K47/20; A61K47/26; A61P35/00
Domestic Patent References:
JPS54101432A1979-08-10
JP2006508917A2006-03-16
JPH05246856A1993-09-24
JPH024796A1990-01-09
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita



 
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