PURPOSE: To provide a pharmaceutical preparation for topical application having prolonged action and useful for the mitigation or prevention of the spasm of muscles, by using a drug layer containing a pressure-sensitive adhesive substance and a nitrite-type vasodilator as essential components, and a flaxible substrate supporting said drug layer.
CONSTITUTION: The objective pharmaceutical preparation for topical application is prepared by applying a drug layer containing a nitrite-type vasodilator (e.g. nitroglycerine, glycol dinitrate, etc.) for the mitigation or prevention of the spasm of muscles and a pressure-sensitive adhesive substance, to a flexible substrate. The thickness of the drug layer is about 10W300μm. The pressure- sensitive adhesive substance is, e.g. an acrylic resin composition, a rubber composition, etc. The vasodilator acts to the diseased part continuously for ≥10hr and the spasm can be effectively prevented by applying the pharmaceutical preparation to the part (e.g. the muscle of the leg) where the spasm is expected.
OOTSUKA SABUROU
YOSHIKAWA TOSHIYUKI
TOKUDA SHIYOUICHI
| JPS5728004A | 1982-02-15 | |||
| JPS5594316A | 1980-07-17 | |||
| JPS57116011A | 1982-07-19 | |||
| JPS5759805A | 1982-04-10 | |||
| JPS57183714A | 1982-11-12 |
| US3742951A | 1973-07-03 |