Title:
医薬的固体状態形態
Document Type and Number:
Japanese Patent JP2011511011
Kind Code:
A
Abstract:
The invention provides and describes solid state 17α-ethynyl-5α-androstane-3α,17β-diol including amorphous and crystalline forms and specific polymorphic forms thereof. Anhydrates and solvates of 17α-ethynyl-5α-androstane-3α,17β-diol include Form III anhydrate and Form I solvate. The invention further relates to solid and suspension formulations containing 17α-ethynyl-5α-androstane-3α,17β-diol in a described solid state form and use of the formulations to treat cancers or precancers such as prostate cancer or breast cancer in subjects or human patients. The invention also relates to methods to make liquid formulations from solid state forms of 17α-ethynyl-5α-androstane-3α,17β-diol and uses of such formulations in treating the described conditions.
Inventors:
White, Stephen K.
Stickney, dwight
Olson, Erin
Lorimar, Keith Earl.
Wolfe, Brenton S.
Stickney, dwight
Olson, Erin
Lorimar, Keith Earl.
Wolfe, Brenton S.
Application Number:
JP2010545285A
Publication Date:
April 07, 2011
Filing Date:
February 05, 2009
Export Citation:
Assignee:
Harbor Biosciences, Inc.
International Classes:
C07J1/00; A61K31/569; A61P35/00
Foreign References:
| US5567830A | 1996-10-22 | |||
| US20080021006A1 | 2008-01-24 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita