置換されたアミドの薬学的使用

Japanese Patent JP2006522746

A

The use of substituted amides for modulating the activity of 11²-hydroxysteroid dehydrogenase type 1 (11²HSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11²HSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.

Andersen, Henrik Sneh
Campen, Gita Camilla Tailgart
Christensen, Inge Sogar
Mogensen, John Patrick
Larsen, Annette Rosendal
Kilburn, John Paul

JP2006504353A

October 05, 2006

April 06, 2004

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NOVO NORDISK AKTIE SELSXAB

C07D209/08; A61K31/16; A61K31/343; A61K31/353; A61K31/403; A61K31/404; A61K31/407; A61K31/41; A61K31/415; A61K31/4155; A61K31/4184; A61K31/427; A61K31/438; A61K31/454; A61K31/46; A61K31/496; A61K31/497; A61K31/5377; A61K31/55; A61K45/06; A61P1/00; A61P1/04; A61P1/08; A61P1/14; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P3/14; A61P5/02; A61P5/14; A61P5/38; A61P7/00; A61P7/04; A61P7/06; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/02; A61P13/12; A61P15/00; A61P15/10; A61P17/00; A61P17/14; A61P19/02; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P25/06; A61P25/08; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P27/06; A61P29/00; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P33/02; A61P35/00; A61P35/02; A61P37/00; A61P37/04; A61P37/06; A61P37/08; A61P39/00; A61P41/00; A61P43/00; C07D209/42; C07D235/08; C07D235/10; C07D235/12; C07D235/14; C07D307/79; C07D311/20; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/12; C07D403/14; C07D405/06; C07D405/14; C07D409/14; C07D413/14; C07D417/06; C07D417/14; C07D451/04; C07D471/10; C07D487/08; C07D491/048

JPS56139483A

1981-10-30

US5260325A	1993-11-09
WO2003000649A1	2003-01-03
WO2000047558A1	2000-08-17
WO2001002385A1	2001-01-11

MASSA, SILVIO, JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. V27 N6, JPN5006002733, 1990, pages 1805 - 1808, ISSN: 0001662793
GIACOMELLI, GIAMPAOLO, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. N3, JPN5006002734, 2003, pages 537 - 541, ISSN: 0001662794

Takehiko Suzue
Satoshi Kono
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Ryo Hashimoto
Tetsuya Kazama

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