Title:
製薬的に許容しうる固定乾燥ヒト血液血小板
Document Type and Number:
Japanese Patent JP4445589
Kind Code:
B2
Abstract:
Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Pharmaceutical formulations containing the same are also disclosed. The platelets are preferably fixed by means of a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by means of a permanganate fixate. The platelets are preferably dried by lyophilization.
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Inventors:
Reed, Marjorie S.
Reddick, Robert El
Board, arthur pee
Reddick, Robert El
Board, arthur pee
Application Number:
JP50054494A
Publication Date:
April 07, 2010
Filing Date:
April 28, 1993
Export Citation:
Assignee:
The University of North Carolina at Chapel Hill
East Carolina University
East Carolina University
International Classes:
A61K35/14; A01N1/02; A61K35/19; A61K38/18; A61L15/40; A61L17/00; A61L26/00; A61L27/22; A61L27/50; A61L27/60; A61L31/00; A61L33/00; C12N5/08
Domestic Patent References:
| JP5878599A | ||||
| JP5247916A |
Foreign References:
| US4287087 | ||||
| US4302355 |
Other References:
Cell,1984,Vol.38,pp.101-108
FASEB Journal ABSTRACTS part II,1990,Vol.4,No.1,p.A1030,#4436
FASEB Journal ABSTRACTS part I,1991,Vol.5,No.1,p.A903, #3093
J.Lab.Clin.Medicine,1975,Vol.85,No.2,pp.318-328
FASEB Journal ABSTRACTS part II,1990,Vol.4,No.1,p.A1030,#4436
FASEB Journal ABSTRACTS part I,1991,Vol.5,No.1,p.A903, #3093
J.Lab.Clin.Medicine,1975,Vol.85,No.2,pp.318-328
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Arihara Koichi
Matsushima Tetsuo