Title:
第II相解毒及び抗酸化活性
Document Type and Number:
Japanese Patent JP2010539102
Kind Code:
A
Abstract:
Provided are methods and compositions that enhance Nrf2 (SKN-1) activation of phase II detoxification or antioxidant enzyme transcription, comprising plant extracts (e.g., willow extracts) or active fractions thereof, as well as methods for identifying additional compounds that increase the Nrf2-regulation of those enzymes.
Inventors:
Blackwell Tea. Keith
Gen Matsumoto
Takeshi Makino
Masashi Goto
Atsushi Ishizuka
Mariko Maeda
Ryo Kanchi
Gen Matsumoto
Takeshi Makino
Masashi Goto
Atsushi Ishizuka
Mariko Maeda
Ryo Kanchi
Application Number:
JP2010524262A
Publication Date:
December 16, 2010
Filing Date:
September 11, 2008
Export Citation:
Assignee:
Joslyn Diabetis Center, Inc.
Sunstar Inc.
Sunstar Inc.
International Classes:
A61K36/18; A23L1/30; A61K8/97; A61P1/16; A61P3/10; A61P9/04; A61P9/10; A61P13/12; A61P17/00; A61P17/18; A61P21/04; A61P25/00; A61P25/08; A61P25/28; A61P39/06; A61P43/00; A61Q5/02; A61Q5/12; A61Q11/00; A61Q19/02; A61Q19/08; A61Q19/10; C12Q1/02; C12Q1/68; G01N30/06; G01N33/15; G01N33/50
Domestic Patent References:
| JP2006290749A | 2006-10-26 | |||
| JP2006117612A | 2006-05-11 | |||
| JP2007119430A | 2007-05-17 | |||
| JP2006241059A | 2006-09-14 |
Foreign References:
| US6646013B1 | 2003-11-11 | |||
| US6046231A | 2000-04-04 |
Other References:
CELL STEM CELL., (2007 AUG) 1[2] P.140-52., JPN6013026715, ISSN: 0002547643
CELL, (2004) 117[4] P.421-6., JPN6013026717, ISSN: 0002547644
J AGRIC FOOD CHEM., (1999) 47[10] P.3954-62., JPN6013026705, ISSN: 0002547638
CARCINOGENESIS, (1997) 18[2] P.451-6., JPN6013026706, ISSN: 0002547639
J AGRIC FOOD CHEM., (1998) 46 P.1893-99., JPN6013026709, ISSN: 0002547640
CELL MOL LIFE SCI., (2007 MAY) 64[9] P.1105-27., JPN6013026710, ISSN: 0002547641
PROC NATL ACAD SCI U S A., (1999) 96[22] P.12731-6., JPN6013026713, ISSN: 0002547642
PLOS GENET., (2007 SEP 28) 3[9] P.1565-71., JPN6013026720, ISSN: 0002547645
CELL, (2004) 117[4] P.421-6., JPN6013026717, ISSN: 0002547644
J AGRIC FOOD CHEM., (1999) 47[10] P.3954-62., JPN6013026705, ISSN: 0002547638
CARCINOGENESIS, (1997) 18[2] P.451-6., JPN6013026706, ISSN: 0002547639
J AGRIC FOOD CHEM., (1998) 46 P.1893-99., JPN6013026709, ISSN: 0002547640
CELL MOL LIFE SCI., (2007 MAY) 64[9] P.1105-27., JPN6013026710, ISSN: 0002547641
PROC NATL ACAD SCI U S A., (1999) 96[22] P.12731-6., JPN6013026713, ISSN: 0002547642
PLOS GENET., (2007 SEP 28) 3[9] P.1565-71., JPN6013026720, ISSN: 0002547645
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office