To obtain a new phenol derivative having excellent lipid peroxidation suppressive activity and macrophage foaming suppressive activity, and useful for preventing/treating ischemic cardiopathy, etc., by reaction of a specific compound with phosgene and so forth.
This new phenol derivative is expressed by formula I [R0 is H, a lower alkyl or a lower alkoxy; R1 is a lower alkyl; W is O, S or NR5 (R5 is H, a lower alkyl, etc.); R21 is a substituted alkyl; R3 is H or a (substituted) lower alkyl], e.g. 2-{3-[2-(4-ethoxycarbonyl methoxyphenyl)ethyl]ureido}-4- methoxyphenol. The phenol derivative is obtained by reaction of a compound (salt) of formula II (R4 is an OH-protecting group) with phosgene, triphosgene or thiophosgene followed by reaction with a compound of formula III to form a compound of formula IV, then eliminating protecting group therefrom.
OMIZU HIROSHI
HASHIMURA YOSHIMASA
KUBOTA HITOSHI
SAITO KEIKO
Next Patent: FORMATION OF BASE