To obtain a new compound having active-oxygen scavenging action and antioxidation action and effective for preventing the cell injury in arteriosclerosis, myocardial infarction and ischemia/reperfusion and suppressing arrhythmia, etc.
This compound is expressed by formula I (R1 and R3 are each a lower alkyl or a lower alkoxy; R2 is H, a lower alkyl or a lower alkoxy; ring A is monocyclic heterocyclic group containing sulfur, nitrogen or oxygen) or its salt, e.g. 7-t-butyl-8-hydroxy-5-methoxy-2-oxo-3-(3-pyridylmethyl)-1,2,3,4- tetrahydroquinazoline hydrochloride. The compound of formula I can be produced by removing protective group of a compound of formula II (R0 is an OH-protecting group). The compound of formula I has excellent lipid peroxidation suppressing action, macrophage foaming suppressing action, oxidized LDL formation suppressing action, ACAT inhibiting action, mouse antioxidation action, action to suppress arrhythmia induced by reperfusion.
OMIZU HIROSHI
HASHIMURA YOSHIMASA
KUBOTA HITOSHI
SAITO KEIKO
