To obtain a new compound useful as a therapeutic agent or a preventing agent for thrombotic diseases, hyperlipemia, arteriosclerotic diseases, etc.
The compound is represented by formula I [R1 is a di-1-6C alkylamino, a (substituted)3-6-membered saturated heterocycle, etc.; R2a to R2c are each H, a (substituted)aryl, etc.; R3a to R3d are each H, a 1-6C alkoxy, etc.; A is a single bond or a 1-6C alkylene], e.g. 1-methyl-2-[2-[4-phenyl-2-(2- phenylmethyl)phenoxy]-ethyl]pyrrolidine. The compound of formula I is obtained by reacting a compound of formula II (R4a to R4c are each R2a to R2c whose hydroxy group is protected), e.g. 4-phenyl-2-(2-phenylthyl)phenol with a compound of formula III (R1a is a protected di-1-6C alkylamino, etc.; Z is a halogen, etc.), e.g. 2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride in an inert solvent in the presence of a base, preferably at 10-80°C for 1-24 hr and carrying out removal, etc., of a protecting group.
| JP6131956 | Amine salt and its crystal |
TANAKA NAOKI
OGAWA TAKETOSHI
TANIMOTO TATSUO
