Title:
選択的セロトニン再取込み阻害剤としてのフェノキシベンジルアミン誘導体
Document Type and Number:
Japanese Patent JP2004507523
Kind Code:
A
Abstract:
A compound of general formula (I) wherein R<1> and R<2> are H, C1-C6alkyl or (CH2)d(C3-C6cycloalkyl) wherein d = 0, 1, 2 or 3; or R<1> and R<2> together with the nitrogen to which they are attached from an azetidine ring; Z or Y is -SR<3> and the other Z or Y is halogen or -R<3>; wherein R<3> is C1-C4 alkyl optionally substituted with fluorine; except that R<3> is not CF3; or Z and Y are linked so that, together with the interconnecting atoms, Z and Y form a fused 5 to 7-membered carbocyclic or heterocyclic ring, and wherein when Z and Y form a heterocyclic ring, in addition to carbon atoms, the linkage contains one or two heteroatoms independently selected from oxygen, sulfur and nitrogen; R<4> and R<5>, which may be the same or different, are: A-X, wherein A = -CH=CH- or -(CH2)p- where p is 0, 1 or 2; X is hydrogen, F, CI, Br, I, CONR<6>R<7>, SO2NR<6>R<7>, SO2NHC(=O)R<6>, OH, C1-4alkoxy, NR<8>SO2R<9>, NO2, NR<6>R<11>, CN, CO2R<10>, CHO, SR<10>, S(O)R<9> or SO2R<10>; or a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O, optionally substituted independently by one or more R<13>; wherein R<13> is hydroxy, C1-C4alkoxy, F, C1-C6alkyl, haloalkyl, haloalkoxy, -NH2, NH(C1-C6alkyl) or -N(C1-C6alkyl)2. The compounds of general formula (I) inhibit monoamine reuptake and in particular exhibit activity as selective serotonin reuptake inhibitors.
Inventors:
Adam, Mavis Diane
Andrews, Mark David
Elliott, Mark Leonard
Zimmer, Geofree Edward
David Hepworth
Howard, Harry Ralph, Junior
Donald Stuart, Middleton
Stove, Alan
Andrews, Mark David
Elliott, Mark Leonard
Zimmer, Geofree Edward
David Hepworth
Howard, Harry Ralph, Junior
Donald Stuart, Middleton
Stove, Alan
Application Number:
JP2002523451A
Publication Date:
March 11, 2004
Filing Date:
August 22, 2001
Export Citation:
Assignee:
Pfizer Inc.
International Classes:
A61K31/135; A61K31/137; A61K31/166; A61K31/18; A61K31/192; A61K31/24; A61K31/275; A61K31/343; A61K31/381; A61K31/39; A61K31/428; A61K31/47; A61K31/517; A61P15/00; A61P15/10; A61P25/00; A61P25/24; A61P25/30; A61P43/00; C07C303/38; C07C311/08; C07C311/37; C07C319/20; C07C323/20; C07D215/20; C07D239/74; C07D277/62; C07D307/87; C07D327/06; C07D333/54; C07D333/72; A61K; C07C; C07D; (IPC1-7): C07C311/08; A61K31/137; A61K31/166; A61K31/18; A61K31/192; A61K31/24; A61K31/275; A61K31/343; A61K31/381; A61K31/39; A61K31/428; A61K31/47; A61K31/517; A61P15/00; A61P15/10; A61P25/00; A61P25/24; A61P25/30; A61P43/00; C07C303/38; C07C311/37; C07C319/20; C07C323/20; C07D215/20; C07D239/74; C07D277/62; C07D307/87; C07D327/06; C07D333/54; C07D333/72
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Kiyoshi Murakami
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Kiyoshi Murakami