Title:
フェニル誘導体及びそれらの医薬としての利用
Document Type and Number:
Japanese Patent JP2010507636
Kind Code:
A
Abstract:
Phenyl derivatives (I) in the form of racemic and/or enantiomeric form and their salts are new. Phenyl derivatives of formula (I) in the form of racemic and/or enantiomeric form and their salts are new. A : heterocyclic moiety of formula (A 1) or phenylic moiety of formula (A 2); X 1-X 4O, S, -NT- or -C(R 4R 5)-; m : 0-1; either R 4, R 5H or 1-6C alkyl (optionally substituted by halo); or R 4R 5=O; T : H, 1-6C alkyl or 1-6C alkyl-carbonyl; R 2H or 1-6C alkyl; R 3a, R 3b, R 3cH, OH, 1-6C alkyl or 1-4C alkoxy; L : -C(O)-O- or a cycle, oxadiazole, oxazole or thiadiazole (all when A is (A 1)) or a cycle, oxadiazole, oxazole or thiadiazole (when A is (A 2)); Y 1covalent bond or -NH-; n : 1-3; R 1-NT 1-C(O)-R 1a, -NT 1-S(O) 2-R 1a, -NT 1-C(Z)-NHR 1a, -C(O)-NH-R 1a or -N=C(NH 2)R 1a; T 1H or 1-4C alkyl; Z : S or O; R 1a1-8C alkyl, 2-6C alkenyl, 1-8C hydroxyalkyl, 3-7C cycloalkyl, spiro-cycloalkyl, 3-7C heterocycloalkyl, 1-8C alkoxy, 1-8C alkoxy-1-8C alkyl or -(CH 2)-R 2a (all optionally substituted by halo or 1-6C (halo)alkyl); p : 1-3; and R 2a3-7C (hetero)cycloalkyl or (hetero)aryl (all optionally substituted by halo, 1-6C alkyl, 1-6C alkoxy or 1-6C haloalkyl). Provided that: when L is -C(O)-O- then Y 1 is a covalent bond; at least one of R 3a, R 3b and R 3c; when R 3c is OH or 1-4C akoxy, then R 1 is -NT 1-C(O)-R 1a, -NT 1-S(O) 2-R 1a or -NT 1-C(Z)-NHR 1a; and the chain -(X 1) m-X 2-X 3-X 4- does not comprise adjacent heteroatoms. [Image] [Image] ACTIVITY : Cytostatic; Immunomodulator; Antiinflammatory; Analgesic; Osteopathic; Gastrointestinal-Gen; Neuroprotective; Muscular-Gen; Antiparkinsonian; Anticonvulsant; Antiemetic; Nootropic. MECHANISM OF ACTION : Cannabinoid receptor (CB2) binder. Tests details are described but no results given.
Inventors:
Reddie Poitou
Jeremiah Harnet
Denny Bigg
Carol soccer
Eric Ferrandis
Jeremiah Harnet
Denny Bigg
Carol soccer
Eric Ferrandis
Application Number:
JP2009533903A
Publication Date:
March 11, 2010
Filing Date:
October 26, 2007
Export Citation:
Assignee:
IPSEN PHARMA S.A.S.
International Classes:
C07C233/07; A61K31/216; A61K31/341; A61K31/353; A61K31/357; A61K31/36; A61K31/381; A61K31/421; A61K31/4245; A61K31/433; A61K31/47; A61K31/538; A61P1/04; A61P19/10; A61P25/00; A61P25/04; A61P25/14; A61P25/16; A61P29/00; A61P35/00; A61P37/02; A61P43/00; C07C231/02; C07C233/09; C07C233/60; C07C233/61; C07C235/14; C07C235/24; C07C273/18; C07C275/32; C07C303/38; C07C311/08; C07C311/14; C07C335/18; C07D215/48; C07D263/32; C07D265/36; C07D271/06; C07D271/10; C07D285/12; C07D307/24; C07D307/52; C07D311/70; C07D317/68; C07D319/18; C07D333/24; C07D413/12
Attorney, Agent or Firm:
Axis International Patent Business Corporation