Title:
フェニル基含有化合物、その中間体，製造方法及び使用
Document Type and Number:
Japanese Patent JP7282977
Kind Code:
B2
Abstract:
A phenyl-containing compound, an intermediate thereof, a preparation method therefor and an application thereof. Provided is a compound represented by formula I or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4 and R5 are independently hydrogen, C1-C6 alkyl, C1-C6 alkoxy or C(=O)OR8; where R8 is C1-C4 alkyl; R6 is (II), (III) or (IV); and R7 is -OH, -NH2, -NHCH3, -N(CH3)2 or C1-4 alkoxy. The compound has a low critical micelle concentration (CMC) and good dilution resistance and is capable of enclosing an insoluble drug to form a small-molecule micelle having a high drug loading capacity and good stability.
Inventors:
Ho Chun
One, Cho Fong
Chao, Yue Chu
Yang, Yarny
Fu, Ching Hoi
Pien, Wei
Chao, Yuan
Koh, Chen
Chan, Yue
Yi, Pin
Niu, Minghao
Chang, Qiu Hui
One, Cho Fong
Chao, Yue Chu
Yang, Yarny
Fu, Ching Hoi
Pien, Wei
Chao, Yuan
Koh, Chen
Chan, Yue
Yi, Pin
Niu, Minghao
Chang, Qiu Hui
Application Number:
JP2022503467A
Publication Date:
May 29, 2023
Filing Date:
July 14, 2020
Export Citation:
Assignee:
SHANGHAI MODERN PHARMACEUTICAL ENGINEERING RESEARCH CENTER CO., LTD.
Shanghai Institute of Pharmaceutical Industry
Shanghai Institute of Pharmaceutical Industry
International Classes:
C07C309/18; A61K31/337; A61K31/704; A61K47/20; A61P35/00; A61P35/04; C07C68/02; C07C69/96; C07C303/22
Domestic Patent References:
| JP2005508287A | ||||
| JP2011507840A | ||||
| JP2011507839A | ||||
| JP2011507838A |
Foreign References:
| WO2004009538A1 | ||||
| DE4032187A1 | ||||
| DE4032187A |
Attorney, Agent or Firm:
Patent Attorney Corporation Taiyo International Patent Office
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