PHENYL-SUBSTITUTED ALKYLCARBOGUANIDIDE HAVING PERFLUOROALKYL GROUP AND PREPARATION THEREOF

Title:

PHENYL-SUBSTITUTED ALKYLCARBOGUANIDIDE HAVING PERFLUOROALKYL GROUP AND PREPARATION THEREOF

Document Type and Number:

Japanese Patent JP3718250

Kind Code:

B2

Abstract:

PURPOSE: To provide a novel phenyl-substd. alkylcarboguanidide having a perfluoroalkyl group suppressing an Na+/H+ exchange mechanism of cells and effective against all of diseases developed by ischemia.
CONSTITUTION: This compd. is represented by formula I [wherein R(A) is H, F, Cl, Br, I, CN, OR(6) (wherein R(6) is H, alkyl, alkenyl, cycloalkyl, phenyl or benzyl), alkyl, cycloalkyl, Or(CH2)aCbF2b+1 (wherein (r) is 0 or 1; (a) is 0-4; and (b) is 1-8) or the like; R(B) is same to R(A); (x) is 1-3; R(1) is H, alkyl, -Ot(CH2)dCeF2e+1 (wherein (t) is 0 or 1; (d) is 0-4; (e) is 1-8) or the like; and R(2)-R(5) are same to R(1)] or a salt thereof, for example 3-(3- trifluoromethylphenyl)propionoguanidide. The compd. represented by formula I is obtained by reacting a compd. represented by formula II (wherein L is an easily uncleophilically substituted group to be removed) with a guanidine and useful as a remedy for arrhythmia, myocardial infarction, angina pectoris, ischemic symptoms or the like.

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Inventors:

Yan-Robert Schievalk
Heinz-Werner Kleman
Hans-Yohen Lang
Andreas Wueichert
Wolfgang Schjorz
Oud Arbus

Application Number:

JP871595A

Publication Date:

November 24, 2005

Filing Date:

January 24, 1995

Export Citation:

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Assignee:

HOECHST AKTIENGESELLSCHAFT

International Classes:

A01N1/02; A61B10/00; A61K31/155; A61P9/06; A61P9/08; A61P9/10; A61K31/165; A61P9/12; A61P35/00; A61P43/00; C07C277/00; C07C279/10; C07C279/22; C07D241/26; G01N33/50; (IPC1-7): C07C279/10; A61K31/165; A61P9/06; A61P9/10; A61P35/00; C07C277/00

Domestic Patent References:

JP56026862A

Foreign References:

DE4301739A1

Attorney, Agent or Firm:

Chika Takagi
Tatsuo Sato
Kosuke Nishimura

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