Title:
PHENYL SUBSTITUTED QUINOLINONECARBONITRILE DERIVATIVE
Document Type and Number:
Japanese Patent JPS55102568
Kind Code:
A
Abstract:
1,2-Dihydro-2-oxo-4-phenyl-3-quinolinecarbonitrile derivatives are provided having the structure wherein (CH2)n represents a straight chain alkylene group containing 2 to 5 carbons, and R1 and R2 are the same or different and may be hydrogen or lower alkyl with the proviso that at least one of R1 and R2 is lower alkyl, or can be taken together to form a heterocyclic radical containing 5- or 6-members in the heterocyclic ring, such as pyrrolidino, piperidino or morpholino, and R3 and R4 may be the same or different and are hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and physiologically acceptable acid addition salts thereof. These compounds are useful as anti-inflammatory agents. A pharmaceutical composition containing the above compounds and a method of use are also provided.
Inventors:
CHIESUTAA EFU TAAKU
JIYON KURAPUCHIYO
JIYON KURAPUCHIYO
Application Number:
JP923380A
Publication Date:
August 05, 1980
Filing Date:
January 28, 1980
Export Citation:
Assignee:
SQUIBB & SONS INC
International Classes:
A61K31/47; A61P29/00; C07D215/54; C07D281/10; (IPC1-7): A61K31/47; A61K31/535; C07D215/48