Title:
PHENYLALANINE DERIVATIVE AND PROTEINASE-INHIBITING AGENT
Document Type and Number:
Japanese Patent JPS63239256
Kind Code:
A
Abstract:
NEW MATERIAL:The compound of formula I [A is H2N, H2NC(=NH) or H2N(C =NH)NH; B is group of formula II, formula III (m is 0W2) or (CH2)n (n is 3W5); X is OH, NO2, NH2, phenoxy, alkyloxy, benzoyl, etc.; Y is NR1R2 (R1 and R2 are H, phenyl, pyridyl, imidazolyl, thiazolyl, alkyl, etc.) or OR3 (R3 is H, alkyl or pyridyl)] or its salt.
EXAMPLE: N-(trans-4-aminomethylcyclohexylcarbonyl)-3-phenoxy-DL-phenylalani ne 4-acetylanilide hydrochloride.
USE: A proteinase inhibitor. It is effective as a remedy for pancreatitis, anti-shock agent, anti-allergic agent, antiulcer agent and immunoregulator.
PREPARATION: The compound of formula I can be produced by combining various methods called as peptide synthesis and ester synthesis.
Inventors:
OKAMOTO AKIYOSHI
OKADA YOSHIO
OKUMIYA AKIKO
NAITO TAKETOSHI
KIMURA YOSHIO
YAMADA MORIHIKO
ONO TOKUO
KATSUURA YASUHIRO
NOJIMA HIROSHI
SHISHIKURA TAKASHI
OKADA YOSHIO
OKUMIYA AKIKO
NAITO TAKETOSHI
KIMURA YOSHIO
YAMADA MORIHIKO
ONO TOKUO
KATSUURA YASUHIRO
NOJIMA HIROSHI
SHISHIKURA TAKASHI
Application Number:
JP7174387A
Publication Date:
October 05, 1988
Filing Date:
March 27, 1987
Export Citation:
Assignee:
SHOWA DENKO KK
OKAMOTO AKIYOSHI
OKAMOTO AKIYOSHI
International Classes:
C07D233/88; A61K31/165; A61K31/195; A61K31/198; A61K31/215; A61K31/22; A61K31/245; A61K31/41; A61K31/415; A61K31/425; A61K31/426; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/495; A61K31/505; A61K31/535; A61K31/5375; A61P1/00; A61P7/04; A61P29/00; A61P43/00; C07C67/00; C07C237/12; C07C237/22; C07C237/24; C07C237/36; C07C239/00; C07C257/14; C07C279/14; C07C279/18; C07D211/34; C07D213/30; C07D213/64; C07D213/68; C07D213/75; C07D213/80; C07D239/42; C07D257/04; C07D257/06; C07D277/20; C07D277/46; C07D295/18; C07K5/06; C07K14/81; (IPC1-7): A61K31/165; A61K31/195; A61K31/215; A61K31/22; A61K31/245; A61K31/41; A61K31/415; A61K31/425; A61K31/44; A61K31/495; A61K31/505; A61K31/535; C07/; C07C103/50; C07C103/737; C07C103/76; C07C123/00; C07C129/12; C07D211/34; C07D213/30; C07D213/64; C07D213/68; C07D213/75; C07D213/80; C07D233/88; C07D239/42; C07D257/06; C07D277/46
Attorney, Agent or Firm:
Aoki Akira