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Title:
PHENYLGLYCINAMIDE OF HETEROCYCLICALLY SUBSTITUTED PHENYLACETIC ACID DERVATIVES
Document Type and Number:
Japanese Patent JPH06329637
Kind Code:
A
Abstract:

PURPOSE: To provide novel compounds useful as active compounds in medicaments, particularly as hypotensor and anti-artherosclerosis agents.

CONSTITUTION: A compound of formula I [wherein A represents alkyl, alkenyl, or cycloalkyl; B represents H, halogen or perfluoroalkyl; D represents CH2-R6 or CO-R7 (wherein R6 represents H or alkyl; R7 represents H, OH or alkoxy); E represents H, halogen, NO2, OH, CF3, alkyl, alkoxy or the like; L represents H or alkyl; R1 represents cycloalkyl or cycloalkyl-substitutable alkyl; R2 represents H or alkyl; R3 represents H, OH, halogen or alkoxy; R4 and R5 are each H, phenyl, pyridyl, cycloalkyl, substitutable alkyl, or they form 6-membered saturated heterocyclic ring containing at most 3 hetero atomes (S, N, O) together with N], for example 2-{2-[4-(2-butyl-4-chloro-5-formyl-imidazole-1-yl- methyl)phenyll-2-cyclopentyl}acetamido-2-phenyl-acetamide of formula II, is provided.


Inventors:
MUELLER ULRICH (DE)
DRESSEL JUERGEN (DE)
FEY PETER (DE)
HANKO RUDOLF (DE)
HUEBSCH WALTER (DE)
KRAEMER THOMAS (DE)
MUELLER-GLIEMANN MATTHIAS (DE)
BEUCK MARTIN (DE)
KAZDA STANISLAV (DE)
WOHLFEIL STEFAN (DE)
KNORR ANDREAS (DE)
STASCH JOHANNES-PETER (DE)
ZAISS SIEGFRIED (DE)
Application Number:
JP7376394A
Publication Date:
November 29, 1994
Filing Date:
March 22, 1994
Export Citation:
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Assignee:
BAYER AG (DE)
International Classes:
A61K31/44; A61K31/4427; A61K31/445; A61K31/495; A61K31/535; A61P9/10; A61P9/12; A61P43/00; C07D233/61; A61K31/415; C07D233/68; C07D233/90; C07D401/12; C07D403/12; C07D413/12; C07D417/12; C07D419/12; C12N9/99; (IPC1-7): C07D233/61; C07D233/68; C07D401/12
Attorney, Agent or Firm:
Heiyoshi Odashima