Title:
ホスファチジルイノシトール３−キナーゼ阻害剤
Document Type and Number:
Japanese Patent JP6454736
Kind Code:
B2
Abstract:
The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein W, B, n, m, A′, R1, R2, and R3 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (PI3K) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more PI3K isoforms.
Inventors:
Kai, Shaopei
Do, Jimin
Kaplan, Joshua
Royer-Drew, Jennifer A.
Nadu Sambi, Devan
Philips, Burton W.
Phillips,gary
Van Wertheizen, Joshua
Watkins, William Jay.
Yen, Soo Chun
Do, Jimin
Kaplan, Joshua
Royer-Drew, Jennifer A.
Nadu Sambi, Devan
Philips, Burton W.
Phillips,gary
Van Wertheizen, Joshua
Watkins, William Jay.
Yen, Soo Chun
Application Number:
JP2016572428A
Publication Date:
January 16, 2019
Filing Date:
June 10, 2015
Export Citation:
Assignee:
Gilead Sciences, Inc.
International Classes:
C07D403/14; A61K31/517; A61K31/519; A61K31/53; A61K31/5377; A61K31/55; A61K31/551; A61P1/04; A61P1/16; A61P1/18; A61P3/04; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/04; A61P11/06; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P17/14; A61P19/00; A61P19/02; A61P21/00; A61P25/00; A61P25/28; A61P29/00; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P43/00; C07D405/14; C07D451/04; C07D471/04; C07D487/04; C07D491/048; C07D495/04; C07D513/04
Domestic Patent References:
| JP2005509635A | ||||
| JP2016503805A | ||||
| JP2017517527A |
Foreign References:
| WO2014023083A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita