Title:
ウィルス感染を治療するためのグアノシンヌクレオシド化合物のホスホルアミダート誘導体
Document Type and Number:
Japanese Patent JP2012514657
Kind Code:
A
Abstract:
Phosphoramidate compounds derived from guanine bases having enhanced therapeutic potency are provided, and these compounds in particular have enhanced potency with respect to treatment of viral infections, such as hepatitis C virus. Pharmaceutical compositions, methods of preparing the compounds, and methods of using the compounds and compositions to treat viral infections are also provided.
Inventors:
Chien Buren, Stanley
Hutchins, jev
Madera, Carolina
McGigan, Christopher
Vernatio, Jiyoung
Algijara, Mohamed
The Giles, Arnaud
Hutchins, jev
Madera, Carolina
McGigan, Christopher
Vernatio, Jiyoung
Algijara, Mohamed
The Giles, Arnaud
Application Number:
JP2011545488A
Publication Date:
June 28, 2012
Filing Date:
January 11, 2010
Export Citation:
Assignee:
University Care of the Cardiff Consultants Limited
International Classes:
C07H19/16; A61K31/7076; A61K31/708; A61P1/16; A61P31/12; A61P31/14; C07H19/167; C07H19/20
Domestic Patent References:
| JP2008504265A | 2008-02-14 | |||
| JP2004533401A | 2004-11-04 | |||
| JP2004510698A | 2004-04-08 | |||
| JP2006514038A | 2006-04-27 | |||
| JP2005537242A | 2005-12-08 |
Foreign References:
| WO2006121820A1 | 2006-11-16 | |||
| WO2008062206A2 | 2008-05-29 |
Other References:
GUNIC,E. ET AL: "6-Hydrazinopurine 2'-methyl ribonucleosides and their 5'-monophosphate prodrugs as potent hepatitis", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 9, JPN6014004382, 2007, pages 2456 - 2458, XP022015324, ISSN: 0002738238, DOI: 10.1016/j.bmcl.2007.02.029
Attorney, Agent or Firm:
Kawaguchi International Patent Office