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Title:
PHYSIOLOGICALLY ACTIVE SUBSTANCE EI-1507S
Document Type and Number:
Japanese Patent JPH07278130
Kind Code:
A
Abstract:

PURPOSE: To obtain new physiologically active substance EI-1507s, having antimicrobial and inhibiting actions on the production of interleukin-1 and useful as a therapeutic agent for chronic articular rheumatism, gout, osteoarthritis, osteoporosis, periarteritis nodosa, colitis ulcerosa, etc.

CONSTITUTION: The physiologically active substance EI-1507s are expressed by the formula (X and Y together are 0 or independently H or OH), e.g. the compound EI-1507-1 in which X and Y together are 0 and the compound EI-1507-7-2 in which X and Y each is H or OH. The compounds expressed by the formula are obtained by culturing a microorganism belonging to the genus Streptomyces. The substance EI-1507s expressed by the formula are useful as a therapeutic agent for symptoms such as chronic nephritis, active chronic hepatitis, sepsis, endotoxic shock, atherosclerosis and pyrexia related to infectious diseases, systemic scleroderma, etc.


Inventors:
TSUKUDA EIJI
TANAKA TATSUHO
OCHIAI KEIKO
ANDO KATSUHIKO
KONDO HIDEMASA
TESHIBA SADAO
AZUMA TSUTOMU
KODA MAYUMI
MATSUDA YUZURU
Application Number:
JP6485894A
Publication Date:
October 24, 1995
Filing Date:
April 01, 1994
Export Citation:
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Assignee:
KYOWA HAKKO KOGYO KK
International Classes:
A61K31/336; A61K31/34; A61P1/12; A61P1/16; A61P9/00; A61P9/10; A61P9/12; A61P13/02; A61P15/00; A61P17/16; A61P19/10; A61P29/00; A61P31/04; A61P43/00; C07D303/32; C12P17/02; C12R1/465; (IPC1-7): C07D303/32