PURPOSE: To obtain new physiologically active substance EI-1507s, having antimicrobial and inhibiting actions on the production of interleukin-1 and useful as a therapeutic agent for chronic articular rheumatism, gout, osteoarthritis, osteoporosis, periarteritis nodosa, colitis ulcerosa, etc.
CONSTITUTION: The physiologically active substance EI-1507s are expressed by the formula (X and Y together are 0 or independently H or OH), e.g. the compound EI-1507-1 in which X and Y together are 0 and the compound EI-1507-7-2 in which X and Y each is H or OH. The compounds expressed by the formula are obtained by culturing a microorganism belonging to the genus Streptomyces. The substance EI-1507s expressed by the formula are useful as a therapeutic agent for symptoms such as chronic nephritis, active chronic hepatitis, sepsis, endotoxic shock, atherosclerosis and pyrexia related to infectious diseases, systemic scleroderma, etc.
TANAKA TATSUHO
OCHIAI KEIKO
ANDO KATSUHIKO
KONDO HIDEMASA
TESHIBA SADAO
AZUMA TSUTOMU
KODA MAYUMI
MATSUDA YUZURU
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