Title:
ＣＤＫ９阻害剤としての多環式アミド誘導体
Document Type and Number:
Japanese Patent JP6997627
Kind Code:
B2
Abstract:
Provided are a series of novel pyridine or pyrimidine derivatives of formula I which inhibit CDK9 and may be useful for the treatment of hyperproliferative diseases. In particular the compounds are of use in the treatment of proliferative diseases such as cancer including hematological malignancies such as acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, diffuse large B cell lymphoma, Burkitt's lymphoma, follicular lymphoma and solid tumors such as breast cancer, lung cancer, neuroblastoma and colon cancer.A is C(R) or N;Ris H, Calkyl, CN or halogen;Ris optionally substituted 3-7 membered heterocycloalkyl or 3-7 membered cycloalkyl;Riswherein X and Y together with the atoms to which they are attached form an optionally substituted, saturated or partially saturated 5 to 7 membered heterocycloalkyl ring which, in addition to the bridge nitrogen, may contain one or two heteroatoms selected from N, O and S;J is N or CR; andRis H or Calkyl.
Inventors:
Kurt Gordon Pike
Bernard Christoph Balram
Janet Hawkins
Christopher De Savi
Melissa Mary Buzzbinder
Alexander Hard
Michelle Lamb
Bernard Christoph Balram
Janet Hawkins
Christopher De Savi
Melissa Mary Buzzbinder
Alexander Hard
Michelle Lamb
Application Number:
JP2017567737A
Publication Date:
January 17, 2022
Filing Date:
June 27, 2016
Export Citation:
Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
C07D471/04; A61K31/4439; A61K31/444; A61K31/4545; A61K31/4985; A61K31/506; A61K31/519; A61K31/5365; A61K31/5383; A61K31/55; A61P35/00; A61P43/00; C07D401/04; C07D487/04; C07D498/04
Foreign References:
| WO2014160017A1 | ||||
| WO2012101063A1 | ||||
| WO2013050434A1 | ||||
| WO2011124539A1 | ||||
| WO2011101640A1 | ||||
| WO2008133192A1 |
Attorney, Agent or Firm:
Michiko Matsutani
Yasushi Ochiai
Yasushi Ochiai