PURPOSE: To obtain a new compound having antimicrobial action and useful as a medicine.
CONSTITUTION: A polyene-based compound expressed by the formula. This compound is obtained by culturing a fungal strain (FERM P-13196) belonging to Streptomyces in a medium containing a nutritive substance under aerobic conditions and extracting the cultured product with an organic solvent (e.g. methanol) and purifying and isolating the product. The compound of the formula has the following physicochemical properties: Appearance, yellow powder; melting point, 128-132°C; molecular formula, C26H33NO6; molecular weight, 455; solubility, soluble in chloroform, ethyl acetate, acetone and methanol and insoluble in water; physiological properties and growth temperature range of the fungal strain, preferably grown in yeast and wheat extract medium at 18-34°C and is not grown at ≤11°C and ≥47°C; biochemical properties: discrimination of aerobic or anaerobic, aerobic; liquefaction of gelatin, positive; solidification of non-fat milk, negative; peptonation of non-fat milk, negative; hydrolysis of starch, positive; formation of melanin-like pigment, negative; type of cell wall, I type; menakinon composition, main components, [MK-9 (H6), MK-9 (H8)].
AKASHI SATOSHI
MIZOGAMI KAZUTOSHI
HANADA KAZUNORI
YAMAGISHI MICHIO
