POLYGLUTAMATED ANTIFOLATES AND USES THEREOF - L E A F HOLDINGS GROUP LLC

Title:

POLYGLUTAMATED ANTIFOLATES AND USES THEREOF

Document Type and Number:

Japanese Patent JP2022126790

Kind Code:

A

Abstract:

To provide compositions for treating diseases including hyperproliferative diseases such as cancer, disorders of the immune system such as rheumatoid arthritis and infectious disease such as HIV.SOLUTION: The disclosure relates generally to polyglutamated antifolates, formulations containing liposomes filled with the polyglutamated antifolates, methods of preparing the polyglutamated antifolates and liposome-containing formulations, and methods of using the polyglutamated antifolates and liposome containing formulations to treat hyperproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).SELECTED DRAWING: None

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Inventors:

CLET NIYIKIZA
VICTOR MANDLA MOYO

Application Number:

JP2022100445A

Publication Date:

August 30, 2022

Filing Date:

June 22, 2022

Export Citation:

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Assignee:

L E A F HOLDINGS GROUP LLC

International Classes:

A61K45/00; A61K9/127; A61K31/517; A61K31/519; A61K31/525; A61K39/39; A61K39/395; A61K47/24; A61K47/26; A61K47/28; A61K47/32; A61K47/34; A61K47/60; A61K47/64; A61K47/68; A61P31/00; A61P35/00; A61P35/02; A61P37/02

Attorney, Agent or Firm:

Ryoichi Takaoka
Nao Oda
Akiyo Iwahori
Kamoto Takahashi

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