Title:
ポリケチド誘導体
Document Type and Number:
Japanese Patent JP2004515459
Kind Code:
A
Abstract:
The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods for their use. The compounds of the present invention are cyclic polyketides (also referred to as a "macrolides" or "macrolactones") that include Formula (I) as part of their structure and bind to a FK binding protein wherein R<4> and R<5> are each selected from the group consisting of hydrogen, methyl, ethyl, and methoxy, provided that at least one of R<4> and R<5> is hydrogen, methyl, or ethyl. As will be explained in greater detail below, the compounds of the present invention have properties such as favorable P450 enzyme activity profiles that are desirable for use of these compounds as drugs.
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Inventors:
Chu, daniel
Fardis, Maria
Kosra, China
Reeves, christopher
Santi, Daniel
Schirmer, Andreas
Fardis, Maria
Kosra, China
Reeves, christopher
Santi, Daniel
Schirmer, Andreas
Application Number:
JP2001584278A
Publication Date:
May 27, 2004
Filing Date:
May 10, 2001
Export Citation:
Assignee:
Kosan Biosciences, Inc.
International Classes:
C12N15/09; A61K31/436; A61P17/00; A61P17/06; A61P25/00; A61P37/06; C07D498/18; C12N1/21; C12R1/465; (IPC1-7): C07D498/18; A61P17/00; A61P17/06; A61P25/00; A61P37/06; C12N1/21; C12N15/09
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita