Title:
カンプトテシン誘導体とＨＳＰ９０阻害剤の結合した高分子化合物及びその用途
Document Type and Number:
Japanese Patent JP6580030
Kind Code:
B2
Abstract:
Provided are: a polymer compound for efficiently delivering two drugs to an affected area, reducing side effects, and increasing drug efficacy; and an antitumor drug having said polymer compound as an active ingredient. This polymer compound is obtained by ester-bonding a camptothecin derivative and an HSP90 inhibitor to a carboxyl group of a side-chain of a block copolymer obtained by joining a polyethylene glycol segment and a polyglutamic acid segment to one another.
More Like This:
Inventors:
Oka saki Manami
Maruyama Sakiko
Ryo Masuda
Keiichiro Yamamoto
Maruyama Sakiko
Ryo Masuda
Keiichiro Yamamoto
Application Number:
JP2016504038A
Publication Date:
September 25, 2019
Filing Date:
February 09, 2015
Export Citation:
Assignee:
NIPPON KAYAKU KABUSHIKI KAISHA
International Classes:
C08G81/00; A61K31/4196; A61K31/4745; A61K47/34; A61K47/60; A61K47/64; A61P35/00
Domestic Patent References:
| JP2010519305A |
Foreign References:
| US20130272993 | ||||
| WO2014073447A1 | ||||
| WO2004039869A1 | ||||
| WO2008041610A1 | ||||
| WO2013067162A1 |
Other References:
K Flatten et al.,The Role of Checkpoint Kinase 1 in Sensitivity to Topoisomerase I Poisons,THE JOURNAL OF BIOLOGICAL CHEMISTRY,2005年,14349-14355
Attorney, Agent or Firm:
Kawaguchi International Patent Office