Title:
POLYMERIZABLE MEDICINE
Document Type and Number:
Japanese Patent JPH07300428
Kind Code:
A
Abstract:
PURPOSE: To obtain a synthetic polymeric drug that can sustain the efficacy of medicine for hours, as its side-effects are inhibited, by retarding the introduction of the active components into cells. CONSTITUTION: This synthetic polymeric drug comprises a bioactive molecule, a targeting moiety and an inert synthetic polymer carrier including the recurring units derived from N-(2-hydroxypropyl)-methacrylamide in which (A) 5.0-99.7 mol.% of the units of formula I, (B) the units bonding 0.2-20.0 mol.% of the bioactive molecule via a peptide space [NH-R-CO] that is hydrolyzable by the intracellular liposome to the polymeric carrer, (C) the units bonding 0.1-94.8 mol.% of a targeting moiety [D] directly or via the target group spacer to the polymer carrier, (D) the units bearing crosslinking chain between 0-5 mol.% of other polymeric carrier of formula IV and (E) the units bonding 0-2 mol.% of N-methacryloyl tyrosine amide to the polymeric carrier as a biologically determining label.
Inventors:
KOPECEK JINDRICH (CS)
REJMANOVA PAVLA (CS)
STROHALM JIRI (CS)
ULBRICH KAREL (CS)
RIHOVA BLANKA (CS)
CHYTRY VLADIMIR (CS)
LLOYD JOHN B (CS)
DUNCAN RUTH (CS)
REJMANOVA PAVLA (CS)
STROHALM JIRI (CS)
ULBRICH KAREL (CS)
RIHOVA BLANKA (CS)
CHYTRY VLADIMIR (CS)
LLOYD JOHN B (CS)
DUNCAN RUTH (CS)
Application Number:
JP14075994A
Publication Date:
November 14, 1995
Filing Date:
May 31, 1994
Export Citation:
Assignee:
CESKOSLOVENSKA AKADEMIE VED (CS)
CANCER RES CAMPAIGN TECH (CS)
CANCER RES CAMPAIGN TECH (CS)
International Classes:
A61K38/00; A61K31/00; A61K31/70; A61K45/00; A61K47/00; A61K47/48; A61P35/00; A61K; (IPC1-7): A61K45/00; A61K31/71; A61K47/48
Attorney, Agent or Firm:
Takehiko Suzue
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