（Ｒ）－２－ヒドロキシ－２－メチル－４－（２，４，５－トリメチル－３，６－ジオキソシクロヘキサ－１，４－ジエニル）ブタンアミドの多形性形態および非晶質形態

Title:

Document Type and Number:

Japanese Patent JP7111759

Kind Code:

B2

Abstract:

Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.

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Inventors:

Paul Morard
Christopher Earl Cornell
Keelon E. Wesson
Peter Zianosis
Shazad skit
Mahmoud Milmerabi

Application Number:

JP2020039715A

Publication Date:

August 02, 2022

Filing Date:

March 09, 2020

Export Citation:

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Assignee:

PTC Therapeutics, Incorporated

International Classes:

C07C235/30; A61K31/16; A61P3/00; A61P3/02; A61P3/10; A61P7/00; A61P7/06; A61P9/00; A61P9/10; A61P13/02; A61P13/12; A61P21/00; A61P21/02; A61P21/04; A61P25/00; A61P25/02; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P27/06; A61P27/16; A61P35/00; A61P39/02; A61P39/06; A61P43/00

Domestic Patent References:

JP2011503005A
JP2011513420A
JP2006526571A
JP10147575A

Attorney, Agent or Firm:

Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto

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