Title:
短鎖脂肪酸の尾部を有するポリミキシン誘導体およびその使用
Document Type and Number:
Japanese Patent JP5752421
Kind Code:
B2
Abstract:
The present invention relates to a polymyxin derivative wherein the derivative has a total of three positive charges at physiological pH and wherein the terminal moiety (D) of the derivative comprises a total of 1 to 5 carbon atoms; and to a combination product comprising at least two such derivatives. The invention further relates to a method for sensitizing Gram-negative bacteria to an antibacterial agent by administering, simultaneously or sequentially in any order a therapeutically effective amount of said antibacterial agent and a derivative according to the present invention to said subject; to methods for developing novel antibiotics; and for sensitizing clinically important bacteria to a host defense mechanism complement present in serum. The invention also relates to a method of treating a subject for a gram-negative bacterial infection by administering a polymyxin derivative of the invention in combination with a second antibacterial agent. Finally, the invention relates to a process for preparing such polymyxin derivatives.
Inventors:
Martti Varra
Timo Vara
Timo Vara
Application Number:
JP2010545515A
Publication Date:
July 22, 2015
Filing Date:
February 05, 2009
Export Citation:
Assignee:
Northern Antibiotics Oy
International Classes:
C07K7/62; A61K38/00; A61K45/00; A61P31/04; A61P43/00
Foreign References:
| US4485039 | ||||
| US20060004185 |
Other References:
JOURNAL OF PEPTIDE RESEARCH,2003年,Vol. 61, No. 6,P. 298-306
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN,2007年,Vol.80, No. 3,P. 543-552
PEPTIDES,2001年,Vol. 22, No. 10,P. 1675-1681
JOURNAL OF MEDICINAL CHEMISTRY,2000年,Vol. 43, No. 16,P. 3085-3092
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN,2007年,Vol.80, No. 3,P. 543-552
PEPTIDES,2001年,Vol. 22, No. 10,P. 1675-1681
JOURNAL OF MEDICINAL CHEMISTRY,2000年,Vol. 43, No. 16,P. 3085-3092
Attorney, Agent or Firm:
Kenji Sugimura
Yoshikazu Takagi
Yoshikazu Takagi