Title:
POLYPEPTIDE AND ANTIBODY DERIVED FROM CHRONIC LYMPHOCYTIC LEUKEMIA CELLS AND USE THEREOF
Document Type and Number:
Japanese Patent JP2012111780
Kind Code:
A
Abstract:
To provide polypeptides and antibodies derived from chronic lymphocytic leukemia cells, and to provide use thereof.
There is provided a method of treating cancer which method includes a step for administering to a subject afflicted with cancer a therapeutic composition that (i) interferes the interaction between CD200 and a CD200 receptor thereby inhibiting the immune suppressing effect of CD200 and (ii) kills cancer cells by using a polypeptide fusion molecule that includes a portion binding to OX-2/CD200 or an OX-2/CD200 receptor.
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Inventors:
BOWDISH KATHERINE S
KRETZ-ROMMEL ANKE
MCWHIRTER JOHN
MARUYAMA TOSHIAKI
KRETZ-ROMMEL ANKE
MCWHIRTER JOHN
MARUYAMA TOSHIAKI
Application Number:
JP2012053212A
Publication Date:
June 14, 2012
Filing Date:
March 09, 2012
Export Citation:
Assignee:
ALEXION PHARMA INC
International Classes:
A61K31/675; A61K45/00; A61K35/28; A61K38/00; A61K38/21; A61K39/00; A61K39/395; A61P35/00; C12Q1/02; C07K16/28
Domestic Patent References:
| JP2001522867A | 2001-11-20 | |||
| JPH0246297A | 1990-02-15 |
Foreign References:
| WO2002059280A2 | 2002-08-01 | |||
| WO2002011762A2 | 2002-02-14 |
Other References:
山口俊晴 外11名: "癌のターゲティング療法の進歩“モノクローナル抗体を利用した癌ミサイル療法のＤＤＳ”", 日本臨床, vol. 56, no. 3, JPN6011059575, March 1998 (1998-03-01), JP, pages 638 - 643, ISSN: 0002611287
山口俊晴 外3名: "臨床応用 治療“腫瘍マーカーを利用した免疫ミサイル療法”", 日本臨床, vol. 54, no. 6, JPN6011059577, June 1996 (1996-06-01), JP, pages 1674 - 1679, ISSN: 0002611288
山口俊晴 外4名: "特集 BRMとBiomedical Modulation“BRMとミサイル療法”", BIOTHERAPY, vol. 10, no. 4, JPN6011059578, April 1996 (1996-04-01), JP, pages 605 - 609, ISSN: 0002611289
RAGHEB,R.，ET AL.: "“Preparation and functional properties of monoclonal antibodies to human, mouse and rat OX-2”", IMMUNOL. LETT., vol. Vol.68，No.2-3, JPN6014026112, 1 June 1999 (1999-06-01), pages 311 - 315, ISSN: 0002840775
山口俊晴 外3名: "臨床応用 治療“腫瘍マーカーを利用した免疫ミサイル療法”", 日本臨床, vol. 54, no. 6, JPN6011059577, June 1996 (1996-06-01), JP, pages 1674 - 1679, ISSN: 0002611288
山口俊晴 外4名: "特集 BRMとBiomedical Modulation“BRMとミサイル療法”", BIOTHERAPY, vol. 10, no. 4, JPN6011059578, April 1996 (1996-04-01), JP, pages 605 - 609, ISSN: 0002611289
RAGHEB,R.，ET AL.: "“Preparation and functional properties of monoclonal antibodies to human, mouse and rat OX-2”", IMMUNOL. LETT., vol. Vol.68，No.2-3, JPN6014026112, 1 June 1999 (1999-06-01), pages 311 - 315, ISSN: 0002840775
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita
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