Title:
Polypeptides derived from TGFβ and their use
Document Type and Number:
Japanese Patent JP6298823
Kind Code:
B2
Abstract:
The present invention relates to the field of Biotechnology and more particularly to the mutated polypeptides of TGF² molecule whose primary sequence has a high homology with the sequence of human TGF². These muteins lose their ability to interact with ALK5 but maintain their ability to interact with other receptors that are part of the receptor complex (T²RII and T²RIII). They have the property of antagonizing the signaling of all natural variants of TGF² ligands, dependent of ALK5 recruitment in the receptor complex, and have significant immunomodulatory effects. The present invention relates to pharmaceutical compositions comprising as active principle the polypeptides or fusion proteins disclosed and their use thereof given their modulating effect on the immune system in diseases such as cancer, diseases accompanied by fibrosis and chronic infectious diseases.
Inventors:
Corlia Osorio, Angel de Jesuit
Leon Monzon, Caret
Carmenate Portilla, Tania
Popo Merinho, Amaury
Perez Rodriguez, Somer
Leon Monzon, Caret
Carmenate Portilla, Tania
Popo Merinho, Amaury
Perez Rodriguez, Somer
Application Number:
JP2015540045A
Publication Date:
March 20, 2018
Filing Date:
October 30, 2013
Export Citation:
Assignee:
Centro de Munologia Molecular
International Classes:
C07K14/495; A61K38/18; A61P31/00; A61P35/00; A61P37/04; A61P43/00; C07K16/00; C07K19/00
Domestic Patent References:
| JP2008237223A | ||||
| JP2011505800A | ||||
| JP2008527978A | ||||
| JP2008509888A |
Foreign References:
| WO2011132189A2 |
Other References:
International Journal of Cancer,2010年,Vol.126,p.1666-1674
Molecular BioSystems,2010年,Vol.6,p.2392-2402
Journal of Investigative Dermatology,2005年,Vol.125,p.450-455
Journal of Cell Science,2000年,Vol.113,p.1101-1109
Genotype mutation analysis of tgf-beta-1 in colonic neoplasia by pcr/sscp,Journal of pathology,1994年,Vol.172(suppl.),p.134a
Cancer Research,2003年,Vol.63,p.2610-2615
Molecular BioSystems,2010年,Vol.6,p.2392-2402
Journal of Investigative Dermatology,2005年,Vol.125,p.450-455
Journal of Cell Science,2000年,Vol.113,p.1101-1109
Genotype mutation analysis of tgf-beta-1 in colonic neoplasia by pcr/sscp,Journal of pathology,1994年,Vol.172(suppl.),p.134a
Cancer Research,2003年,Vol.63,p.2610-2615
Attorney, Agent or Firm:
Asamura patent office
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