Title:
ポリペプチド及びその使用
Document Type and Number:
Japanese Patent JP2013505286
Kind Code:
A
Abstract:
The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from a naturally occurring protein which modulates blood coagulation, or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant or derivative thereof, for use in the treatment or prevention of inflammation and/or excessive coagulation of the blood. Related aspects of the invention provide isolated polypeptides comprising or consisting of an amino acid sequence of SEQ ID NOS: 1 to 3, or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant or derivative thereof, which exhibit an anti-inflammatory activity, together with isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of inflammation and/or excessive coagulation.
Inventors:
Martina Carre
Nils Martin Malmsten
Plavin Papa Lady
Victoria Lüdengord
Artur Schmidtchen
Björn Uhlick Valse
Nils Martin Malmsten
Plavin Papa Lady
Victoria Lüdengord
Artur Schmidtchen
Björn Uhlick Valse
Application Number:
JP2012530326A
Publication Date:
February 14, 2013
Filing Date:
September 22, 2010
Export Citation:
Assignee:
Excel Mune Actie Borrag
International Classes:
C07K14/81; A61K31/56; A61K38/00; A61K45/00; A61L17/00; A61L29/00; A61P7/02; A61P9/00; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P17/02; A61P31/00; A61P37/08; A61P43/00; C12N15/09; C12P21/02
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi