Title:
POLYPEPTIDES WITH ENHANCED ANTI-INFLAMMATORY AND DECREASED CYTOTOXIC PROPERTIES AND RELATING METHODS
Document Type and Number:
Japanese Patent JP2015038086
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To produce a polypeptide containing IgG Fc region, the polypeptide having a higher anti-inflammatory activity and a lower cytotoxicity compared to an unpurified antibody.SOLUTION: IgG sialylation is shown to be regulated by the induction of an antigen-specific immune response, and the cytotoxic and anti-inflammatory response of the IgG Fc domain are shown to result from the different sialylation of the Fc-linked core polysaccharide. The cytotoxicity of the IgG antibody is reduced by sialylation; on the contrary the anti-inflammatory activity is enhanced. The polypeptide has high sialic acid content compared to the unpurified antibody, including the Fc region of human IgG1, IgG2, IgG3, or IgG4.
Inventors:
JEFFREY V RAVETCH
KANEKO YOSHIMASA
FALK NIMMERJAHN
KANEKO YOSHIMASA
FALK NIMMERJAHN
Application Number:
JP2014182741A
Publication Date:
February 26, 2015
Filing Date:
September 08, 2014
Export Citation:
Assignee:
UNIV ROCKEFELLER
International Classes:
C07K16/00
Foreign References:
| WO2002030954A1 | 2002-04-18 |
Other References:
JPN6014018092; Ａｎｎｕ Ｒｅｖ Ｂｉｏｐｈｙｓ Ｂｉｏｍｏｌ Ｓｔｒｕｃｔ． Ｖｏｌ．２４, 1995, ｐ．５５１-５７７
JPN6012037052; Ｂｉｏｃｈｅｍ Ｂｉｏｐｈｙｓ Ｒｅｓ Ｃｏｍｍｕｎ． Ｖｏｌ．２８６， Ｎｏ．２, 20010817, ｐ．２４３-２４９
JPN6013012205; Ｍｏｌ Ｉｍｍｕｎｏｌ． Ｖｏｌ．４４， Ｎｏ．７, 20061011, ｐ．１５２４-１５３４
JPN6012037052; Ｂｉｏｃｈｅｍ Ｂｉｏｐｈｙｓ Ｒｅｓ Ｃｏｍｍｕｎ． Ｖｏｌ．２８６， Ｎｏ．２, 20010817, ｐ．２４３-２４９
JPN6013012205; Ｍｏｌ Ｉｍｍｕｎｏｌ． Ｖｏｌ．４４， Ｎｏ．７, 20061011, ｐ．１５２４-１５３４
Attorney, Agent or Firm:
Hatta international patent business corporation
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