Title:
POLYSACCHARIDE DEPOLYMERIZATION AND SULFATATION
Document Type and Number:
Japanese Patent JPS59133201
Kind Code:
A
Abstract:
Novel depolymerized and supersulfated heparin having a molecular weight comprised between 2000 and 9000 and a sulfation degree of at least 2.5, in which all of the primary hydroxy groups are sulfated; a process for its preparation by reacting a heparin of natural origin, or a fraction thereof with a sulfuric acid/chlorosulfonic acid mixture; and pharmaceutical compositions containing it as active ingredient, having potential antithrombotic, hypolipemic and fibrinolytic activity and useful in the prevention of thrombosis and for the treatment of atherosclerosis.
Inventors:
ANNAMARIA NAGII
JIYAN JIYAAKOMO TORI
JIYAN JIYAAKOMO TORI
Application Number:
JP25244783A
Publication Date:
July 31, 1984
Filing Date:
December 28, 1983
Export Citation:
Assignee:
ANIC SPA
SANOFI SA
SANOFI SA
International Classes:
A61K31/715; A61P3/06; A61P7/02; C08B31/06; A61P7/04; C08B37/00; C08B37/10; (IPC1-7): A61K31/725; C08B31/06; C08B37/00
Domestic Patent References:
| JPS4730167A | ||||
| JPS56803A | 1981-01-07 | |||
| JP58252446A |
Attorney, Agent or Firm:
Yumi Kaida (1 outside)
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