Title:
多糖―ペプチド複合体
Document Type and Number:
Japanese Patent JP4290766
Kind Code:
B2
Abstract:
The invention relates to a polysaccharide-peptide conjugate wherein the polysaccharide is advantageously immunogenic, which comprises a polysaccharide chain composed of repeat units and a plurality of peptide moieties, each moiety containing a cysteine residue and being covalently attached at random along the polysaccharide chain, through an indirect bond being achieved through either a linker or a spacer-linker moiety provided that the spacer entity of the spacer-linker moiety is linked to the amino, hydroxyl or carboxyl group of the polysaccharide. To this end a useful linker may be, e.g., N-(gamma-maleimidobutyrloxy)succinimide ester. Such a conjugate may typically exhibit a "Rake" configuration. Conjugation processes are also disclosed. Conjugates of the invention are in particular useful in the vaccinal field to elicit a protective long term immune response against a pathogenic microorganism from which the Immunogenic polysaccharide is derived.
Inventors:
Morrow, Monik
Mistretta, Noel
Mistretta, Noel
Application Number:
JP53376898A
Publication Date:
July 08, 2009
Filing Date:
January 21, 1998
Export Citation:
Assignee:
SANOFI PASTEUR
International Classes:
A61K39/385; C07K14/00; A61K31/00; A61K31/715; A61K47/48; A61P37/00; A61P37/02; C12N15/00
Domestic Patent References:
| JP4243897A | ||||
| JP61186400A |
Foreign References:
| EP0326111A1 |
Attorney, Agent or Firm:
Aoyama Aoi
Mitsuo Tanaka
Mitsuo Tanaka
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