Title:
選択される生物分子のバイオアベイラビリティを低減させるための多孔性親和性ヒドロゲル粒子
Document Type and Number:
Japanese Patent JP7272608
Kind Code:
B2
Abstract:
A hydrogel particle that has an average cross-sectional diameter in the range from 1 micrometer (μm) to 1000 μm, wherein the particle includes a first polymer network with an average mesh size that allows diffusion of a molecule with an hydrodynamic radius of 1000 nanometer (nm) or less into the first polymer network and which particle includes one or more binding molecules that are immobilized by the polymer network. The hydrogel particle preferably has wherein the first polymer network has an average mesh size that prevents diffusion of a molecule with an average hydrodynamic radius of more than 1000 nm to diffuse into the first polymer network, preferably the mesh size prevents diffusion of a molecule with an average hydrodynamic radius of more than 100 nm, and preferably more than 5 nm. Methods for reducing the bioavailability of one or more soluble biological molecules in a biological system by using the described hydrogel particle.
Inventors:
Kampermann Tom
Calvert Leesanne Paula
Calperine Hermanus Bernardus Johannes
Layten Jern Christianus Hermanus
Dijkstra Pieter Jelle
Zute beer bram
Calvert Leesanne Paula
Calperine Hermanus Bernardus Johannes
Layten Jern Christianus Hermanus
Dijkstra Pieter Jelle
Zute beer bram
Application Number:
JP2020560858A
Publication Date:
May 12, 2023
Filing Date:
January 18, 2019
Export Citation:
Assignee:
Higrek 2 Sea LA Besroten Fennot Shap
International Classes:
C08J3/075; A61K9/08; A61K9/14; A61K38/02; A61K39/395; A61K47/60; A61K47/61; A61P5/00; A61P29/00; A61P35/00; A61P37/06
Domestic Patent References:
| JP2016507585A | ||||
| JP2003503367A | ||||
| JP10147518A |
Foreign References:
| WO2016172143A1 | ||||
| EP2111872A2 | ||||
| WO2007024008A1 |
Attorney, Agent or Firm:
Sykes Patent Attorney Corporation