POTASSIUM CHANNEL-CONTROLLING MEDICINE

Title:

POTASSIUM CHANNEL-CONTROLLING MEDICINE

Document Type and Number:

Japanese Patent JP2010053042

Kind Code:

A

Abstract:

To provide a new compound having a potassium channel-controlling activity, especially a BK channel opening activity, and useful as a medicine, to provide a method for synthesizing the compound, to provide an intermediate useful for synthesizing the compound, and to provide a medicine composition containing the compound.

There are provided the compound represented by formula (I) (wherein, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are especially defined), or its salt acceptable as a medicine, or its solvate.

Inventors:

OWADA TOMOHIKO
CUI YONG-MEI
YASUTOMI ERIKO

Application Number:

JP2008216532A

Publication Date:

March 11, 2010

Filing Date:

August 26, 2008

Export Citation:

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Assignee:

UNIV TOKYO

International Classes:

C07C62/34; A61K31/192; A61K31/235; A61K31/4453; A61P9/10; A61P11/06; A61P13/10; A61P37/08; A61P43/00; C07C61/40; C07C69/753; C07C69/757; C07C229/50; C07C251/44; C07C275/42; C07C335/22; C07D295/04

Domestic Patent References:

JP2002510464A	2002-04-09
JP2000511886A	2000-09-12

Foreign References:

US2478978A	1949-08-16
US20030125357A1	2003-07-03

Other References:

JPN6013027748; Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ　Ｌｅｔｔｅｒｓ１８（１９）, ５１９７-５２００
JPN6013027749; Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ　Ｌｅｔｔｅｒｓ１８（１９）, ５２０１-５
JPN6013027752; Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ　Ｌｅｔｔｅｒｓ１８（２４）, ６３８６-９
JPN6009050610; Ｓｙｎｔｈｅｔｉｃ　Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ２８（４）, 1998, ｐ．６３９-６５２
JPN6009050616; Ａｕｓｔｒａｌｉａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｃｈｅｍｉｓｔｒｙ２６（８）, 1973, ｐ．１７６３-１７６９
JPN6009050615; Ｂｕｌｌｅｔｉｎ　ｏｆ　ｔｈｅ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ　ｏｆ　Ｊａｐａｎ６０（７）, 1987, ｐ．２４０１-２４０７

Attorney, Agent or Firm:

Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takumi Terachi

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