Title:
mGluR2アンタゴニストとしてのピリジン及びピリミジン誘導体
Document Type and Number:
Japanese Patent JP5249919
Kind Code:
B2
Abstract:
The present invention relates to compounds of formula (I), a process for the manufacture thereof, their use for the preparation of medicaments for treating CNS disorders and pharmaceutical compositions containing them:
wherein A, B, X, Y, R 1 , R 2 , R 3 and R 4 are as defined in the description and claims.
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Inventors:
Gatti MacArthur, Sylvia
Getch, Erwin
Wichmann, Jurgen
Voltering, Thomas Johannes
Getch, Erwin
Wichmann, Jurgen
Voltering, Thomas Johannes
Application Number:
JP2009502014A
Publication Date:
July 31, 2013
Filing Date:
March 19, 2007
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D213/26; A61K31/44; A61K31/4418; A61K31/4439; A61K31/444; A61K31/4545; A61K31/496; A61K31/505; A61K31/5377; A61P25/00; A61P25/08; A61P25/18; A61P25/20; A61P25/28; A61P35/00; A61P43/00; C07D213/32; C07D213/53; C07D213/70; C07D213/73; C07D401/04; C07D401/10; C07D401/14; C07D409/10; C07D409/14; C07D413/04; C07D413/10; C07D413/14; C07D417/04; C07D417/10; C07D417/14
Domestic Patent References:
| JP2005526081A | ||||
| JP1265018A | ||||
| JP2005154606A |
Foreign References:
| US20030055085 | ||||
| WO1993011433A1 | ||||
| WO2004039914A1 | ||||
| US5521189 | ||||
| GB2376886A |
Other References:
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BAGLEY M C,SYNLETT 2003,ドイツ,2003年,N2,P259-261
FUNABIKI K,JOURNAL OF THE CHEMICAL SOCIETY.PERKIN TRANSACTIONS I,2001年,P2578-2582
WENKERT E,JOURNAL OF ORGANIC CHEMISTRY,1985年,V50,P1125-1126
T.ROSS KELLY,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,1985年,V107,P4998-4999
KROEHNKE,FRITZ,SYNTHESIS,1976年 1月,P1-24
Inorganic Reaction Mechanisms,2003年,5,21-30
Polyhedron,2003年,22,93-108
J. Chem. Soc. Perkin Trans. 2,2001年,1045-1050
Eur. J. Med. Chem.,1997年,32,965-972
J. Am. Chem. Soc.,1997年,119,8253-8268
Tetrahedron Lett.,1990年,31,3919-3922
Tetrahedron,1989年,45,1783-1792
J. Org. Chem.,1967年,32,1591-1596
SPIVEY ALAN C,ORGANIC & BIOMOLECULAR CHEMISTRY,2003年 5月 1日,V1 N10,P1638-1640
BAGLEY M C,SYNLETT 2003,ドイツ,2003年,N2,P259-261
FUNABIKI K,JOURNAL OF THE CHEMICAL SOCIETY.PERKIN TRANSACTIONS I,2001年,P2578-2582
WENKERT E,JOURNAL OF ORGANIC CHEMISTRY,1985年,V50,P1125-1126
T.ROSS KELLY,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,1985年,V107,P4998-4999
KROEHNKE,FRITZ,SYNTHESIS,1976年 1月,P1-24
Attorney, Agent or Firm:
Patent business corporation Tsukuni
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Toshio Miyake
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Akio Shibata
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Toshio Miyake
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Akio Shibata
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