PURPOSE: To prepare the titled compound useful as a synthetic intermediate for cephalosporin antibiotic substances under mild conditions in a short time, by directly deacylating the side chain at the 7-position of cephalosporin C biologically without oxidizing the amino group at the 5-position in the side chain at the 7-position of the cephalosporin C.
CONSTITUTION: A cephalosporin C derivative of the formula (R is H or isobutoxycarbonyl; M1 and M2 are H or alkali metallic atom) is reacted in the presence of a culture of a microorganism e.g. Paecilomyces sp. C-2106 (FERM-P No.6693), having the ability to produce 7-amino-cephalosporanic acid (hereinafter referred to as 7-ACA) by deacylating the cephalosporin C derivative, and belonging to the genus Paecilomyces or a treated material thereof in an aqueous medium preferably at 6.5W7.5pH and 33W37°C to prepare the aimed 7-ACA.
FUKUO TSUYOSHI
KUNITOU KAZUYA
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