Title:
Pキラル性ホスホランの調製および不斉合成でのその使用
Document Type and Number:
Japanese Patent JP2007530657
Kind Code:
A
Abstract:
Materials and methods for preparing P-chirogenic monophospholanes and bisphospholanes are disclosed. The methods employ stereoselective cyclization to generate the phospholane rings followed by pyramidal inversion to access a variety of P-chirogenic phospholanes. When bound to transition metals such as rhodium, the disclosed P-chirogenic phospholanes may be used as catalysts in asymmetric synthesis of valuable pharmaceutical chemical entities, including pregabalin.
Inventors:
Garret Stewart Hodge
Application Number:
JP2007505651A
Publication Date:
November 01, 2007
Filing Date:
March 23, 2005
Export Citation:
Assignee:
Warner-Lambert Company Limited Liability Company
International Classes:
C07F9/6568; C07D327/10; C07F9/02; C07F15/00
Attorney, Agent or Firm:
Yoshinobu Murofushi
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