Title:
PREPARATION OF ACID AMIDE
Document Type and Number:
Japanese Patent JPS5782350
Kind Code:
A
Abstract:
PURPOSE: To obtain an acid amide useful as an anticonvulsant and a hypnotic in high yield without preparing by-products, by reacting an organic acid ester with ammonia or an amine in the presence of an alcoholate of an alkali metal.
CONSTITUTION: A bicyclo[2,2,1]heptene-5-carboxylic acid ester-2 shown by the formula (R is alkyl, aryl or aralkyl) is reacted with ammonia or a primary amine or secondary amine (e.g., methylamine, ethylamine, aniline, pyridine, etc.) in the presence of an alcoholate of an alkali metal (e.g., NaOCH3) at 10W150°C, preferably at 40W100°C, to give bicyclo[2,2,1]heptene-5-carboxylic acid amide-2. The amount of the alcoholate of an alkali metal used is preferably 5W20mol% based on the ester.
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Inventors:
TAKAHASHI NOBUTO
Application Number:
JP15817780A
Publication Date:
May 22, 1982
Filing Date:
November 12, 1980
Export Citation:
Assignee:
KOJIN KK
International Classes:
C07C231/02; C07C67/00; C07C231/00; C07C233/58; C07D295/18; (IPC1-7): C07C102/04; C07C103/19; C07C103/737; C07D295/18
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