Title:
PREPARATION OF AZOMETHINE COMPOUND
Document Type and Number:
Japanese Patent JPS5888347
Kind Code:
A
Abstract:
PURPOSE: To obtain the titled compound useful as a raw material for preparing an antagonist cimetidine, by reacting N-cyano-methylamino-ethyleneimino-azomethine with hydrogen chloride or a hydrogen chloride donor.
CONSTITUTION: N-Cyano-methylamino-ethyleneimino-azomethine of formulaIis reacted with hydrogen chloride or a hydrogen chloride donor, e.g. pyridine hydrochloride which is a hydrochloride of an organic tertiary amine, in a solvent, e.g. methanol, chloroform or benzene, at room temperatureW50°C, preferably 40W50°C, to give an azomethine compound N-cyano-methylamino-2'-chloroethylamino-azomethine which is the aimed substance of formula II.
Inventors:
FUNATSUKURI GIICHI
FUKUI RIYUUICHI
TAKAMATSU SHIYUUHEI
SAKAI TAKESHI
SHIGEARI TOSHIMITSU
SEKI KOUICHI
FUKUI RIYUUICHI
TAKAMATSU SHIYUUHEI
SAKAI TAKESHI
SHIGEARI TOSHIMITSU
SEKI KOUICHI
Application Number:
JP18588581A
Publication Date:
May 26, 1983
Filing Date:
November 19, 1981
Export Citation:
Assignee:
FUJIMOTO SEIYAKU KK
International Classes:
C07C261/04; C07C67/00; C07C239/00; (IPC1-7): C07C125/08
Attorney, Agent or Firm:
Miyazaki Shinhachiro