Title:
PREPARATION OF CRYSTAL FORM-1 RANITIDINE HYDROCHLORIDE
Document Type and Number:
Japanese Patent JP2514901
Kind Code:
B2
Abstract:
PURPOSE: To prepare a pure crystal form-1 ranitidine hydrochloride having good filtering and drying characteristics.
CONSTITUTION: The crystallization is carried out from a solution of ranitidine hydrochloride in a mixed solvent of 1 pt. of at least one lower alkanol such as ethanol with 1-2.0 pts. of a 6-10C aromatic hydrocarbon such as toluene in the presence of a seed crystal of a pure crystal form-1 ranitidine hydrochloride to thereby prepare the pure crystal form-1 ranitidine hydrochloride. The solution of the ranitidine hydrochloride is preferably prepared by conducting a former step for adding hydrochloric acid in an amount of 0.8-1.15 equiv., preferably 0.95-1.0 equiv. based on 1 equiv. of the ranitidine free base to a solution of the ranitidine free base or its soluble salt in the mixed solvent.
Inventors:
TENNKOO GOOI
JEFURII DEBITSUDO MATSUKUGOORITSUKU
KASHIMIIRU ANCHATSUKU
JEEMUZU ROON ANSONII CHINDARU
JEFURII DEBITSUDO MATSUKUGOORITSUKU
KASHIMIIRU ANCHATSUKU
JEEMUZU ROON ANSONII CHINDARU
Application Number:
JP19390693A
Publication Date:
July 10, 1996
Filing Date:
July 12, 1993
Export Citation:
Assignee:
TOOKAN CHEM LTD
International Classes:
C07D307/52; C07B63/00; (IPC1-7): C07D307/52
Domestic Patent References:
| JP6272680A | ||||
| JP5791983A |
Attorney, Agent or Firm:
Masao Miyake