Title:
PREPARATION OF D-(-)-4-HYDROXYPHENYLGLYCINE AND L-(+)-4-HYDROXYPHENYLGLYCINE FROM D,L-4-HYDROXYPHENYLGLYCINE
Document Type and Number:
Japanese Patent JP3043449
Kind Code:
B2
Abstract:
PURPOSE: To prepare D.L.-hydroxyphenylglycine hydrosulphate in an aq. soln. by warming and then cooling. To the soln., seed crystals are added to crystalline either of D and L forms. It is then filtered off. Other seed crystals are added to the remaining filtrate and then filtered off. Thus objective D-(-), L-(+) isomers are obtained.
CONSTITUTION: D,L-4-Hydroxyphenylglycine hydrosulphate is made as a warm soln. in a solvent contg. 0-30% of water. Then, it is cooled. Seed crystals of an enantiomeric hydrosulphate to be crystallized out during cooling the added in a small amount. Thereafter, formed crystals are filtered off and separated. Then, the filtrate contg. L-(+)-4-hydroxyphenylglycine is heated, to which an aq. soln. contg. D,L-4-hydroxyphenylglycine and sulfuric acid is added. It is then cooled. Furthermore, crystals of L-(+)-isomer to be crystallized are added and cooled furthermore, to crystallize L-(+)-4-hydroxyphenylglycine hydrosulphate. This method is advantageous industrially since seed materials are used in a relatively low amount. the D-(-) isomer is used for preparation of antibiotics, and L-(+)-isomer is oxfenicine that is a medicament for treating cardiac diseases.
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Inventors:
Gerard Kessel
Application Number:
JP5724191A
Publication Date:
May 22, 2000
Filing Date:
March 20, 1991
Export Citation:
Assignee:
Gerard Kessel
International Classes:
C07C227/34; C07C227/42; C07C229/40; (IPC1-7): C07C229/40; C07C227/34
Domestic Patent References:
| JP5328140A | ||||
| JP4725147A | ||||
| JP51113839A | ||||
| JP51113840A |
Attorney, Agent or Firm:
Tadahiko Ito