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Patent Searching and Data


Title:
PREPARATION OF DONOR OF BIODEGRADABLE DRUG
Document Type and Number:
Japanese Patent JPS6036410
Kind Code:
A
Abstract:

PURPOSE: To provide the titled donor capable of releasing the drug in a living body under controlled condition, by dissolving chitin in a solvent, contacting the obtained dope with a coagulating liquid to obtain swollen chitin, impregnating the swollen chitin with a drug-containing solution, and drying the product.

CONSTITUTION: Chitin (poly-N-acetyl-D-glucosamine) is dissolved in a solvent (e.g. trichloroacetic acid), and the obtained dope is charged in a pressure tank and extruded with a gear pump, etc. through a sepcific die into a coagulating liquid (e.g. water, alcohol, ketone, etc.) to obtain a swollen product having the form of rod, ring, sheet, etc. The product is impregnated with a solution containing a drug (e.g. proteinous drug, anti-infective, carcinostatic agent, remedy for ophthalmic diseases, etc.), and dried to obtain the objective donor. When the donor is brought ino contact with a body fluid, it releases the drug slowly over a lont time into the body fluid, and finally the donor itself also disappears. The releasing period can be adjusted.


Inventors:
KIBUNE KOUJI
Application Number:
JP14542883A
Publication Date:
February 25, 1985
Filing Date:
August 08, 1983
Export Citation:
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Assignee:
UNITIKA LTD
International Classes:
A61K9/20; A61K9/18; A61K9/22; A61K47/36; (IPC1-7): A61K9/18