Title:
PREPARATION OF MAYTANSINOL
Document Type and Number:
Japanese Patent JPS5529972
Kind Code:
A
Abstract:
PURPOSE: To prepare maytansinol, by treating maytanacine, maytansinol propionate or ansamitocin antibiotics with microorganisms which belong to the genus Streptomyces.
CONSTITUTION: Maytanacine, maytansinol propionate, or ansamitocin antibiotics are brought into contact with a culture of microorganisms, e.g. Streptomyces coelicolor ATCC-13405 (IFO 3807), which belong to the genus Streptomyces, and have the ability to convert the acyloxy group at the 3-position into the hydroxy group, or its treated substance.
Inventors:
NAKAHAMA KAZUO
IZAWA MIKIO
KIDA MAKOTO
IZAWA MIKIO
KIDA MAKOTO
Application Number:
JP10354778A
Publication Date:
March 03, 1980
Filing Date:
August 24, 1978
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD
International Classes:
C12P17/18; C12R1/465; (IPC1-7): C12P17/18; C12R1/465
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