Title:
PREPARATION METHOD FOR 5ALPHA-PREGNANE DERIVATIVE
Document Type and Number:
Japanese Patent JP2005289901
Kind Code:
A
Abstract:
To provide a method for preparing a 5α-pregnane derivative used as an intermediate for preparing squalamine having a strong antimicrobial activity and a carcinostatic activity.
A metal selected from among alkali metals and alkaline earth metals is reacted with (20S)-7α, 21-dihydroxy-20-methylpregna-1, 4-dien-3-one in the presence of an amine and/or ammonia to prepare (20S)-7α, 21-dihydroxy-20-methyl-5α-pregnan-3-one represented by formula II.
Inventors:
NAKAZAWA MAKOTO
KOYAKUMARU KENICHI
KOYAKUMARU KENICHI
Application Number:
JP2004108416A
Publication Date:
October 20, 2005
Filing Date:
March 31, 2004
Export Citation:
Assignee:
KURARAY CO
International Classes:
C07J7/00; C07J75/00; (IPC1-7): C07J7/00; C07J75/00
Domestic Patent References:
JP2002201199A | 2002-07-16 |
Foreign References:
WO2002020552A1 | 2002-03-14 |
Attorney, Agent or Firm:
Takashima Ichi
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