PREPARATION OF NOVEL DERIVATIVES OF NNSUBSTITUTED CARBOXYLIC ACID AMIDE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME WITH BLOOD SUGAR AND * OR LIPID LOWERING ACT1ION

Japanese Patent JPS535148

A

1530062 Tricyclic carboxylic acid amides BOEHRINGER MANNHEIM GmbH 4 April 1977 [2 July 1976] 14161/77 Heading C2C Novel compounds I: wherein A is a valency bond or an oxygen or sulphur atom or a methylene, ethylene, vinylene, ethyleneoxa or methylenethia radical, V is a straight-chain or branched, saturated or unsaturated trivalent hydrocarbon radical containing up to 4 carbon atoms, R 1 and R 2 , which may be the same or different, are hydrogen or halogen atoms, hydroxyl groups or alkyl or alkoxy radicals, R 3 is a hydrogen atom, a hydroxyl group or an alkoxy radical, Y is a branched or unbranched alkylene radical containing up to 3 carbon atoms, X is a valency bond or a straight-chain or branched; saturated or unsaturated divalent aliphatic hydrocarbon radical containing up to 6 carbon atoms and D is a hydroxymethyl, formyl, free or esterified carboxyl or N- substituted carbamoyl radical; and the physiologically compatible salts thereof, are prepared by acylation, reactions involving the formation or conversion of the -X-D group, hydrogenation or salification. Pharmaceutical compositions having hypoglycaemic and/or hypolipidaemic activity, for oral or parenteral activity, comprise a compound I together with a pharmaceutical carrier.

MANFUREETO HIYUPUNAA
RUUTO HEERUTO
ERUMAARU BOJIISU
HANSU KIYUUNRE
FUERITSUKUSU HERUMUUTO SHIYUMI

JP3938277A

January 18, 1978

April 06, 1977

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BOEHRINGER MANNHEIM GMBH

A61K31/16; A61K31/165; A61K31/195; A61K31/215; A61K31/35; A61K31/352; A61K31/38; A61K31/55; A61P3/08; C07C233/12; C07C233/60; C07C233/63; C07D311/82; C07D311/84; C07D311/90; C07D313/12; C07D335/12; C07D335/20; C07D337/12; (IPC1-7): A61K31/13; A61K31/35; A61K31/38; A61K31/55; C07C103/19; C07D311/82; C07D313/12; C07D337/12

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