PURPOSE: To obtain the titled compound which is a synthetic raw material of a sulfur-containing amino acid derivative useful as a hypotensor, etc., in high purity, by reacting a specific optically active halogen compound with a thiosulfate or a trithiocarbonate, and hydrolyzing the reaction product with an acid.
CONSTITUTION: An optically active compound of formulaI(X is halogen; n is 1W3; R1 is H or 1W4C alkyl; R2 is H or 1W4C alkyl; provided that when R1 is H, then R2 is not H; R3 is carboxyl, etc.) is made to react either with a thiosulfate to obtain the compound of formulaI-1 (Mis alkali metal, alkaline earth metal or ammonium) or with a trithiocarbonate to obtain the compound of formulaI-2. The reaction product is hydrolyzed with an acid (e.g. hydrochloric acid) to obtain the objective compound of formula II. The use of a thiosulfate or trithiocarbonate as a thiolation agent is effective to suppress the by-production of monosulfide compounds and to keep the optical activity of the raw material compound and the objective compound.
SHIMAZAKI MASAMI
NOMURA KENJI
KAN KAZUNORI
WATANABE KIYOSHI
