Title:
小さな結晶の調製
Document Type and Number:
Japanese Patent JP2005524519
Kind Code:
A
Abstract:
Small crystals are made by mixing a solution of a desired substance with an anti-solvent in a fluidic vortex mixer in which the residence time is less than 1s, for example 10 ms. The liquid within the fluidic vortex mixer ( 12 ) is subjected to high intensity ultrasound from a transducer ( 20, 22 ). The solution very rapidly becomes supersaturated, and the ultrasound can induce a very large number of nuclei for crystal growth. Small crystals, for example less than 5 mum, are formed. The resulting suspension is treated so as to add or remove ingredients, and then spray dried using an atomizer tuned to create small droplets in such a way that each droplet should contain not more than one crystal. Crystal agglomeration is hence prevented.
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Inventors:
McCausland Linda Jane
Ray david
Ray david
Application Number:
JP2004501028A
Publication Date:
August 18, 2005
Filing Date:
April 08, 2003
Export Citation:
Assignee:
Accentus Public Limited Company
International Classes:
F26B17/10; A61K9/16; B01D1/18; B01D9/00; B01D9/02; C07D499/18; C07D499/46; F26B3/12; (IPC1-7): B01D1/18; B01D9/02; F26B17/10
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama