Title:
1,3,5-トリアジン-2,4,6-トリオンの性腺刺激ホルモン放出ホルモンレセプターアンタゴニストとしての調製および使用
Document Type and Number:
Japanese Patent JP4328617
Kind Code:
B2
Abstract:
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1, R2, R3a, R3b, R4, R5, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
Inventors:
Guo, Zie Can
Wu, Don Pay
Chain, chain
Tucci, Fabioce.
Reagan, Colin
Wu, Don Pay
Chain, chain
Tucci, Fabioce.
Reagan, Colin
Application Number:
JP2003517031A
Publication Date:
September 09, 2009
Filing Date:
August 02, 2002
Export Citation:
Assignee:
Neurocline Biosciences, Inc.
International Classes:
C07D251/34; A61K31/53; A61P1/00; A61P3/14; A61P5/06; A61P5/24; A61P5/26; A61P5/30; A61P5/32; A61P5/34; A61P5/36; A61P9/12; A61P11/00; A61P13/08; A61P15/00; A61P15/08; A61P15/10; A61P15/18; A61P19/08; A61P25/20; A61P35/00; A61P37/02; A61P43/00; C07D401/06; C07D401/12; C07D403/06; C07D403/12; C07D409/06; C07D417/04; C07D417/10; C07D417/14
Domestic Patent References:
| JP2000511532A | ||||
| JP9025270A |
Other References:
Journal of Heterocyclic Chemistry,1977年,Vol.14, No.6,p.989-992
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita