Title:
Prevention medicine of the Breton type tyrosine kinase
Document Type and Number:
Japanese Patent JP6042995
Kind Code:
B2
Abstract:
This application discloses the Btk inhibitor compounds 6-tert-Butyl-8-fluoro-2-{3-hydroxymethyl-4-[1-methyl-5-(1′-methyl-1′,2′,3′,4′,5′,6′-hexahydro-[3,4′]bipyridinyl-6-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-pyridin-2-yl}-2H-phthalazin-1-one, 2-(2-{3-[5-(5-Azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl]-2-hydroxy methyl-phenyl}-8-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile, and 6-tert-Butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxy-ethylamino)-methyl]-pyridin-2-ylamino}-6-oxo-1,6-dihydro-pyridin-3-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one, formulations thereof, and methods of treatment of asthma, as described herein.
Inventors:
Year, Raman Mahadevan
Rain, Draman Ibrahim
Lopez-Tapier, Francisco Hubbie
Philips, Jonathan Yee
Stevenson, Christopher
Rain, Draman Ibrahim
Lopez-Tapier, Francisco Hubbie
Philips, Jonathan Yee
Stevenson, Christopher
Application Number:
JP2015542318A
Publication Date:
December 14, 2016
Filing Date:
November 27, 2013
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
A61K31/4725; A61K9/72; A61K45/00; A61K47/26; A61P11/06; A61P43/00; C07D401/14
Domestic Patent References:
| JP2009532489A | ||||
| JP2012519200A | ||||
| JP2011511027A |
Foreign References:
| WO2012020008A1 | ||||
| WO2011160920A1 | ||||
| WO2010074113A1 | ||||
| WO2012156334A1 |
Attorney, Agent or Firm:
Patent business corporation Tsukuni
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